Abstract In oncology, most drugs are judged by whether they shrink tumors, delay progression, or prolong survival. Far fewer can be said to have helped produce documented cure. A true cure in cancer medicine usually means durable complete remission with long-term survival and a very low likelihood of relapse after adequate follow-up. By that strict standard, only a small number of drugs have earned a special place in medical history. The clearest examples are methotrexate in

Introduction Cancer is not a single disease but a collection of disorders driven by genetic instability, chronic inflammation, oxidative stress, immune evasion, altered metabolism, resistance to cell death, angiogenesis, invasion, and metastasis. Because of this complexity, many researchers have become interested in multi-target natural compounds that can influence several cancer-related pathways at once rather than hitting only one molecular target. ( pmc.ncbi.nlm.nih.gov )